PERSISTENCE AND REACTIVATION OF RICKETTSIA TSUTSUGAMUSHI INFECTIONS IN LABORATORY MICE
نویسندگان
چکیده
منابع مشابه
Persistence and reactivation of Rickettsia tsutsugamushi infections in laboratory mice.
The persistence of R. tsutsugamushi in tissues of experimentally infected mice for 565 days was demonstrated. Reactivation of apparently dormant infections was accomplished by inoculating the mice with a heterologous strain of the organism or treatment with cyclophosphamide.
متن کاملDetection of Rickettsia tsutsugamushi in Experimentally infected mice by PCR.
We developed a rapid procedure for the detection of Rickettsia tsutsugamushi DNA by the PCR technique. The primer pair used for the PCR was designed from the DNA sequence of the gene encoding a 120-kDa antigen, which was proven to be group specific by immunoblot analysis with mouse hyperimmune sera against various rickettsial strains. This PCR method was able to detect up to 10 ag of plasmid DN...
متن کاملCharacterization of factors determining Rickettsia tsutsugamushi pathogenicity for mice.
Pathogenicity of Rickettsia tsutsugamushi for laboratory mice is known to be influenced by at least three factors: (i) route of inoculation, (ii) antigenic strain, and (iii) natural resistance of the host. By using Karp, Gilliam, and Kato strains of R. tsutsugamushi, we examined the effect of these three pathogenicity factors on the kinetics of infection and the development of immunity in BALB/...
متن کاملPathologic study of mice infected with Rickettsia tsutsugamushi R19 strain.
Scrub typhus, an acute febrile infectious disease caused by R. tsutsugamushi, has been reported from various parts of the far east and pacific rim of Asia including Korea. It is well known that all human pathogenic rickettsia share an affinity to endothelial cells of the small blood vessels and evoke vascular inflammation variably associated with a rash, microthrombi, and hemorrhage. We infecte...
متن کاملComparative susceptibility to mouse interferons of Rickettsia tsutsugamushi strains with different virulence in mice and of Rickettsia rickettsii.
Three strains of Rickettsia tsutsugamushi (Karp, Gilliam, and TA716, representing three virulence types in mice) were examined for their sensitivity to the inhibitory effects of recombinant gamma interferon (IFN-gamma) and purified IFN-alpha/beta in two cultured mouse fibroblast cell lines. The susceptibilities of another species, Rickettsia rickettsii, and of encephalomyocarditis virus (EMCV) ...
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ژورنال
عنوان ژورنال: Japanese Journal of Medical Science and Biology
سال: 1979
ISSN: 0021-5112,1884-2828
DOI: 10.7883/yoken1952.32.179